Best response to the Nimzo-Indian Defense: Rubinstein System (E41)

1. d4 Nf6 2. c4 e6 3. Nc3 Bb4 4. e3 c5 · White to move

What is the best response to the Nimzo-Indian Defense: Rubinstein System (1. d4 Nf6 2. c4 e6 3. Nc3 Bb4 4. e3 c5)? White to move. See the top replies ranked by opening theory and real-game results, starting with Ne2.

The main theoretical reply is Ne2, reaching the Nimzo-Indian Defense: Rubinstein System, Rubinstein Variation.