Best response to the Queen's Gambit Accepted: Alekhine Defense (D22)

1. d4 d5 2. c4 dxc4 3. Nf3 a6 · White to move

What is the best response to the Queen's Gambit Accepted: Alekhine Defense (1. d4 d5 2. c4 dxc4 3. Nf3 a6)? White to move. See the top replies ranked by opening theory and real-game results, starting with e4.

The main theoretical reply is e4, reaching the Queen's Gambit Accepted: Alekhine Defense, Borisenko-Furman Variation.