Best response to the Queen's Gambit Declined: Orthodox Defense, Classical Variation (D68)

1. d4 d5 2. c4 e6 3. Nc3 Nf6 4. Bg5 Be7 5. e3 O-O 6. Nf3 Nbd7 7. Rc1 c6 8. Bd3 dxc4 9. Bxc4 Nd5 10. Bxe7 Qxe7 11. O-O Nxc3 12. Rxc3 e5 · White to move

What is the best response to the Queen's Gambit Declined: Orthodox Defense, Classical Variation (1. d4 d5 2. c4 e6 3. Nc3 Nf6 4. Bg5 Be7 5. e3 O-O 6. Nf3 Nbd7 7. Rc1 c6 8. Bd3 dxc4 9. Bxc4 Nd5 10. Bxe7 Qxe7 11. O-O Nxc3 12. Rxc3 e5)? White to move. See the top replies ranked by opening theory and real-game results, starting with Qc2.

The main theoretical reply is Qc2, reaching the Queen's Gambit Declined: Orthodox Defense, Classical Variation.