Best response to the Queen's Gambit Declined: Semi-Tarrasch Defense (D40)

1. d4 Nf6 2. c4 e6 3. Nf3 d5 4. Nc3 c5 · White to move

What is the best response to the Queen's Gambit Declined: Semi-Tarrasch Defense (1. d4 Nf6 2. c4 e6 3. Nf3 d5 4. Nc3 c5)? White to move. See the top replies ranked by opening theory and real-game results, starting with cxd5.

The main theoretical reply is cxd5, reaching the Queen's Gambit Declined: Semi-Tarrasch Defense.