Best response to the Sicilian Defense: Kan Variation, Knight Variation (B43)

1. e4 c5 2. Nf3 e6 3. d4 cxd4 4. Nxd4 a6 5. Nc3 · Black to move

What is the best response to the Sicilian Defense: Kan Variation, Knight Variation (1. e4 c5 2. Nf3 e6 3. d4 cxd4 4. Nxd4 a6 5. Nc3)? Black to move. See the top replies ranked by opening theory and real-game results, starting with Nc6.

The main theoretical reply is Nc6, reaching the Sicilian Defense: Taimanov Variation.