Best response to the Sicilian Defense: Open (B32)

1. e4 c5 2. Nf3 Nc6 3. d4 cxd4 4. Nxd4 · Black to move

What is the best response to the Sicilian Defense: Open (1. e4 c5 2. Nf3 Nc6 3. d4 cxd4 4. Nxd4)? Black to move. See the top replies ranked by opening theory and real-game results, starting with Nf6.

The main theoretical reply is Nf6, reaching the Sicilian Defense: Open.