Best response to the Slav Defense (D10)

1. d4 d5 2. c4 c6 3. Nc3 dxc4 · White to move

What is the best response to the Slav Defense (1. d4 d5 2. c4 c6 3. Nc3 dxc4)? White to move. See the top replies ranked by opening theory and real-game results, starting with e4.

The main theoretical reply is e4, reaching the Slav Defense: Slav Gambit, Alekhine Attack.

Ranked replies for White